Neuroprotection After Traumatic Brain Injury: Is There any Hope?

Author

Department of Neurology, Kashan University of Medical Sciences, Kashan, Iran

Abstract

Traumatic brain injury (TBI), whatever its cause, is already
associated usually with disability and death worldwide.[1] The
mechanism of injury in TBI includes primary and secondary
injuries. The primary brain injury usually appears just when
the trauma is occurred. Common mechanisms comprise direct
impact, rapid acceleration/deceleration, penetrating injury, and
shock waves. The damage that results include a combination
of focal contusions and hematomas, as well as shearing of
white matter tracts (diffuse axonal injury) along with cerebral
edema and swelling.[2] While effective in managing the primary
injury to the brain and the skull, these treatment modalities
do not address the complex secondary cascades that occur at
a cellular level following initial injury and greatly affect the
ultimate neurologic outcome.

Keywords


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