Neuroprotection After Traumatic Brain Injury: Is There any Hope?

Author

Department of Neurology, Kashan University of Medical Sciences, Kashan, Iran

10.4103/atr.atr_6_18

Abstract

Traumatic brain injury (TBI), whatever its cause, is already
associated usually with disability and death worldwide.[1] The
mechanism of injury in TBI includes primary and secondary
injuries. The primary brain injury usually appears just when
the trauma is occurred. Common mechanisms comprise direct
impact, rapid acceleration/deceleration, penetrating injury, and
shock waves. The damage that results include a combination
of focal contusions and hematomas, as well as shearing of
white matter tracts (diffuse axonal injury) along with cerebral
edema and swelling.[2] While effective in managing the primary
injury to the brain and the skull, these treatment modalities
do not address the complex secondary cascades that occur at
a cellular level following initial injury and greatly affect the
ultimate neurologic outcome.

Keywords

References

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History

  • Receive Date: 21 May 2018
  • Accept Date: 21 May 2018

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