TY - JOUR ID - 62197 TI - The Relationship Between Serum Levels of Interleukins 6, 8, 10 and Clinical Outcome in Patients With Severe Traumatic Brain Injury JO - Archives of Trauma Research JA - ATR LA - en SN - 2251-953X AU - Yousefzadeh-Chabok, Sharhokh AU - Dehnadi Moghaddam, Anoush AU - Kazemnejad-Leili, Ehsan AU - Saneei, Zahra AU - Hosseinpour, Marieh AU - Kouchakinejad-Eramsadati, Leila AU - Razzaghi, Alireza AU - Mohtasham-Amiri, Zahra AD - Neurosurgery Department, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran AD - Anesthesiology Department, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran AD - Biostatistics Department,Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran AD - Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran AD - Human Resource Management, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran Y1 - 2015 PY - 2015 VL - 4 IS - 1 SP - EP - KW - head injury KW - interleukin KW - brain DO - 10.5812/atr.18357 N2 - Background Clinical outcome in patients with severe traumatic brain injury (TBI) depends on both primary and secondary brain injuries. Neuroinflammation is an important secondary mechanism, which occurs by releasing interleukins (ILs). Increased levels of ILs may affect clinical outcome following TBI. Objectives This study aimed to determine the relationship between the serum levels of interleukins 6, 8 and 10 and clinical outcome in patients with severe TBI 6 months after injury. Patients and Methods In a descriptive-analytical study, 44 patients with GCS ≤ 8 (Glasgow coma scale) and age ≥ 14 years were included. Their blood samples were collected at first 6 hours after injury. Clinical outcome was determined based on GOS (Glasgow Outcome Scale) at 6 months after head injury. Serum levels of interleukins 6, 8 and 10 were measured using the ELISA method. Spearman's rho, independent T-Test, and Mann-Whitney Test were used for data analysis. Results Comparing the serum levels of interleukins in two groups with favorable and unfavorable clinical outcomes showed that the mean serum levels of interleukins 6 and 8 in group with favorable outcome was 85.2 ± 51.6 and 52.2 ± 31.9, respectively lower than those of group with unfavorable outcome with 162.3 ± 141.1 and 173.6 ± 257.3 (P < 0.03) and (P < 0.01). Conclusions Increased serum levels of interleukins 6 and 8 as a predictive marker might be associated with unfavorable clinical outcome in patients with severe TBI. UR - https://archtrauma.kaums.ac.ir/article_62197.html L1 - https://archtrauma.kaums.ac.ir/article_62197_210a41b22ed6501343c7d5888748eeee.pdf ER -